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噬菌体T5的单链DNA结合蛋白的鉴定:对T5复制的意义。

Identification of the ssDNA-binding protein of bacteriophage T5: Implications for T5 replication.

作者信息

Werten Sebastiaan

机构信息

Institute for Biochemistry; University of Greifswald; Greifswald, Germany.

出版信息

Bacteriophage. 2013 Oct 1;3(4):e27304. doi: 10.4161/bact.27304. Epub 2013 Dec 9.

Abstract

In a recent study, we identified and characterized the long-elusive replicative single-stranded DNA-binding protein of bacteriophage T5, which we showed is related to the eukaryotic transcription coactivator PC4. Here, we provide an extended discussion of these data, report several additional observations and consider implications for the recombination-dependent replication mechanism of the T5 genus, which is still poorly understood.

摘要

在最近的一项研究中,我们鉴定并表征了噬菌体T5长期难以捉摸的复制性单链DNA结合蛋白,我们发现它与真核转录共激活因子PC4相关。在此,我们对这些数据进行了扩展讨论,报告了一些额外的观察结果,并思考了对T5属依赖重组的复制机制的影响,目前人们对该机制仍知之甚少。

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