State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
J Nat Prod. 2014 Feb 28;77(2):200-5. doi: 10.1021/np400487a. Epub 2014 Jan 31.
Eight new glucosylated coumaroyltyramine derivatives, teuvissides A-H (1-8), were isolated from whole plants of Teucrium viscidum. Their structures were elucidated using spectroscopic data and chemical methods. The antihyperglycemic activities of these compounds were evaluated in HepG2 cells and 3T3-L1 adipocytes, and all of the isolates elicited different levels of glucose consumption at a concentration of 2.0 μM. Teuvissides A (1), B (2), and F (6) induced 2.2-, 2.1-, and 2.2-fold changes, respectively, in the levels of glucose consumption in HepG2 cells and 2.5-, 2.1-, and 2.3-fold changes, respectively, in 3T3-L1 adipocytes relative to the basal levels.
从粘毛荆芥（Teucrium viscidum）全株中分离得到了 8 个新的葡萄糖基化肉桂酰酪胺衍生物，teuvissides A-H（1-8）。采用光谱数据和化学方法阐明了它们的结构。在 HepG2 细胞和 3T3-L1 脂肪细胞中评价了这些化合物的抗高血糖活性，所有分离物在 2.0 μM 浓度下均表现出不同程度的葡萄糖消耗。Teuvissides A（1）、B（2）和 F（6）分别诱导 HepG2 细胞中葡萄糖消耗水平增加 2.2、2.1 和 2.2 倍，在 3T3-L1 脂肪细胞中分别增加 2.5、2.1 和 2.3 倍，与基础水平相比。
