Feng Wei-Sheng, Pei Yuan-Yuan, Zheng Xiao-Ke, Li Chun-Ge, Ke Ying-Ying, Lv Yan-Yan, Zhang Yan-Li
a School of Pharmacy, Henan University of Traditional Chinese Medicine , Zhengzhou 450046 , China.
J Asian Nat Prod Res. 2014;16(4):393-9. doi: 10.1080/10286020.2013.823951. Epub 2013 Aug 6.
A new apiose-containing kaempferol trioside, kaempferol-3-O-α-L-rhamnosyl-(1‴ → 6″)-O-β-D-galactopyranosyl-7-O-β-D-apiofuranoside, along with 16 known compounds, were isolated from 50% acetone extract of Silphium perfoliatum L. Their structures were elucidated by acid hydrolysis and spectroscopic techniques including UV, IR, MS, ¹H, ¹³C, and 2D-NMR. In addition, the pharmacological activity of compound 1 was tested with HepG2 and Balb/c mice (splenic lymphocytes and thymic lymphocytes) in vitro, and it exhibited inhibitory effect on the proliferation of HepG2 cells and showed the immunosuppressive activity.
从串叶松香草50%丙酮提取物中分离得到一种新的含芹糖的山柰酚三糖苷，即山柰酚-3-O-α-L-鼠李糖基-(1‴→6″)-O-β-D-吡喃半乳糖基-7-O-β-D-芹糖呋喃糖苷，以及16个已知化合物。通过酸水解和光谱技术（包括紫外、红外、质谱、¹H、¹³C和二维核磁共振）对其结构进行了鉴定。此外，对化合物1的药理活性进行了体外实验，以HepG2细胞以及Balb/c小鼠（脾淋巴细胞和胸腺淋巴细胞）为对象，结果表明该化合物对HepG2细胞的增殖具有抑制作用，并具有免疫抑制活性。
