Doksöz Önder, Güzel Orkide, Yılmaz Ünsal, Işgüder Rana, Çeleğen Kübra, Meşe Timur
Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
Department of Pediatric Neurology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
Pediatr Neurol. 2014 Apr;50(4):343-6. doi: 10.1016/j.pediatrneurol.2013.12.005. Epub 2013 Dec 10.
Limited data are available on the effects of a ketogenic diet on dispersion duration of P-wave and QT-interval measures in children. We searched for the changes in these measures with serial electrocardiograms in patients treated with a ketogenic diet.
Twenty-five drug-resistant patients with epilepsy treated with a ketogenic diet were enrolled in this study. Electrocardiography was performed in all patients before the beginning and at the sixth month after implementation of the ketogenic diet. Heart rate, maximum and minimum P-wave duration, P-wave dispersion, and maximum and minimum corrected QT interval and QT dispersion were manually measured from the 12-lead surface electrocardiogram.
Minimum and maximum corrected QT and QT dispersion measurements showed nonsignificant increase at month 6 compared with baseline values. Other previously mentioned electrocardiogram parameters also showed no significant changes.
A ketogenic diet of 6 months' duration has no significant effect on electrocardiogram parameters in children. Further studies with larger samples and longer duration of follow-up are needed to clarify the effects of ketogenic diet on P-wave dispersion and corrected QT and QT dispersion.
关于生酮饮食对儿童P波离散时间和QT间期测量值的影响，现有数据有限。我们通过连续心电图来探究接受生酮饮食治疗的患者这些测量值的变化。
本研究纳入了25例接受生酮饮食治疗的耐药癫痫患者。在生酮饮食开始前及实施生酮饮食6个月后，对所有患者进行心电图检查。从12导联体表心电图中手动测量心率、最大和最小P波时限、P波离散度、最大和最小校正QT间期以及QT离散度。
与基线值相比，第6个月时最小和最大校正QT及QT离散度测量值虽有增加，但无统计学意义。其他上述心电图参数也未显示出显著变化。
为期6个月的生酮饮食对儿童心电图参数无显著影响。需要进行更大样本量和更长随访时间的进一步研究，以阐明生酮饮食对P波离散度、校正QT及QT离散度的影响。
