Özdemir Rahmi, Güzel Orkide, Küçük Mehmet, Karadeniz Cem, Yılmaz Ünsal, Calik Tansel, Meşe Timur
Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
Department of Pediatric Neurology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
Neuropediatrics. 2016 Jun;47(3):157-61. doi: 10.1055/s-0036-1582139. Epub 2016 Apr 4.
Background The association between ketogenic diet (KD) and prolonged QT interval, life-threatening ventricular arrhythmias, and sudden death is controversial. Aim We aimed to prospectively evaluate the effect of KD on electrocardiography (ECG) measures in children with refractory epilepsy. Method A total of 70 children with drug-resistant epilepsy who received a KD for at least 12 months were included in the study. The standard 12-lead electrocardiography was performed in all patients before the beginning and in the 12th month of KD. Heart rate, P-wave duration and dispersion, corrected QT interval and QT dispersion, and Tp-e interval were measured. Results All ECG-derived parameters, but P-wave dispersion increased after 12 months of KD compared with the baseline values. However, these changes were not statistically significant. Conclusion A 12-month long 3:1 KD treatment exerts no deleterious effect on cardiac repolarization measures.
背景 生酮饮食（KD）与QT间期延长、危及生命的室性心律失常及猝死之间的关联存在争议。目的 我们旨在前瞻性评估KD对难治性癫痫患儿心电图（ECG）指标的影响。方法 本研究纳入了70例接受KD治疗至少12个月的耐药性癫痫患儿。在KD开始前及KD治疗第12个月时，对所有患者进行标准12导联心电图检查。测量心率、P波时限及离散度、校正QT间期及QT离散度，以及Tp-e间期。结果 与基线值相比，KD治疗12个月后，除P波离散度外，所有ECG衍生参数均有所增加。然而，这些变化无统计学意义。结论 为期12个月的3:1 KD治疗对心脏复极指标无不良影响。
