Genética Molecular, Hospital Universitario Central Asturias-Servicio de Salud del Principado de Asturias, Oviedo, Spain.
J Invest Dermatol. 2011 May;131(5):1003-5. doi: 10.1038/jid.2011.14.
The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C_LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis.
表皮分化复合体基因簇位于染色体 1q21.3 区域，PSORS4 基因座也定位于此。一个常见的 LCE 基因（LCE3C_LCE3B-del）缺失与银屑病相关。该缺失纯合的个体对外源性物质的皮肤屏障反应受损，促进了银屑病特征性的全身性皮肤炎症。
