Research assistant, Department of Orthodontics, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Professor, Department of Orthodontics, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Am J Orthod Dentofacial Orthop. 2014 Feb;145(2):179-87. doi: 10.1016/j.ajodo.2013.10.011.
Some chronic diseases are associated with changes in the morphology of sella turcica, and type 1 diabetes is the most common chronic disease in children and adolescents. Therefore, the aim of this study was to evaluate the size and morphology of sella turcica in patients with type 1 diabetes compared with a healthy control group.
The study included 76 type 1 diabetic patients (38 boys, 38 girls; ages, 14.16 ± 2.46 years) and 76 controls (38 boys, 38 girls; ages, 14 ± 2.08 years). The groups were categorized as pubertal and postpubertal according to bone age. The length, height, and diameter of sella turcica were measured. Then the morphology of sella turcica was analyzed and categorized as normal, oblique anterior wall, bridging, double contour of the floor, irregularity in the posterior part of dorsum sellae, or pyramidal shape of the dorsum sellae. All measurements were made on tracings of cephalometric radiographs. Differences between the groups were tested with the Mann-Whitney U test. Categorical data were evaluated with the Fisher exact test, and the Bonferroni correction was made. The significance level was assigned as P <0.05.
There was no statistically significant difference in the dimensions of sella between the diabetic patients (diameter, 12.20 ± 1.49 mm; length, 10.49 ± 1.55 mm; height, 8.07 ± 1.25 mm) and the controls (diameter, 12.45 ± 1.43 mm; length, 10.90 ± 1.73 mm; height, 8.29 ± 1.66 mm). However, diameter and length increased with age in the overall assessment. Length was greater in the postpubertal controls (11.39 ± 1.69 mm) compared with the pubertal controls (10.41 ± 1.64 mm). Diameter was greater in the postpubertal diabetic patients (1.283 ± 1.55 mm) than in the pubertal diabetic patients (11.56 ± 1.12 mm) and was specifically higher in postpubertal boys. Normal sella morphology was less common in general in the diabetic patients, particularly in the diabetic boys and diabetic pubertal boys (P <0.05).
The measurements concerning sella were similar in the type 1 diabetic and control subjects, but dysmorphologic types were more common in diabetic patients.
一些慢性疾病与蝶鞍形态的变化有关，1 型糖尿病是儿童和青少年中最常见的慢性疾病。因此，本研究旨在评估与健康对照组相比，1 型糖尿病患者的蝶鞍大小和形态。
本研究纳入了 76 例 1 型糖尿病患者（男 38 例，女 38 例；年龄 14.16±2.46 岁）和 76 例对照者（男 38 例，女 38 例；年龄 14±2.08 岁）。根据骨龄将两组分为青春期前和青春期后。测量蝶鞍的长度、高度和直径。然后分析蝶鞍的形态，并分为正常、前壁倾斜、桥接、颅底双重轮廓、鞍背后部不规则或鞍背后部金字塔形。所有测量均在头颅侧位片的描记图上进行。采用 Mann-Whitney U 检验比较两组间的差异。采用 Fisher 确切检验评估分类数据，并进行 Bonferroni 校正。赋值 P<0.05 为差异有统计学意义。
糖尿病患者（直径 12.20±1.49mm；长度 10.49±1.55mm；高度 8.07±1.25mm）与对照组（直径 12.45±1.43mm；长度 10.90±1.73mm；高度 8.29±1.66mm）之间的蝶鞍尺寸无统计学差异。然而，总体评估中直径和长度随年龄增加而增加。青春期后对照组的长度（11.39±1.69mm）大于青春期对照组（10.41±1.64mm）。青春期后糖尿病患者的直径（1.283±1.55mm）大于青春期糖尿病患者（11.56±1.12mm），特别是青春期后男性患者的直径更大。蝶鞍形态异常在糖尿病患者中更为常见，特别是在男性糖尿病患者和青春期前男性糖尿病患者中（P<0.05）。
1 型糖尿病患者与对照组的蝶鞍测量值相似，但蝶鞍形态异常在糖尿病患者中更为常见。
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