Quast U, Cook N S
Cardiovascular Unit, Sandoz Ltd, Basle, Switzerland.
Life Sci. 1988;42(7):805-10. doi: 10.1016/0024-3205(88)90654-6.
The effect of the crude venom of the Israeli scorpion Leiurus quinquestriatus hebraeus on the 86Rb+ efflux stimulated by the K+ channel opener BRL 34915 in the rat portal vein was examined. Applied alone, the venom greatly increased the spontaneous mechanical activity of and the concomitant 86Rb+ efflux from the vessel. When the excitability of the vein was suppressed by the dihydropyridine calcium antagonist, PN 200-110, the 86Rb+ efflux stimulated by BRL 34915 could be shown to be inhibited by the venom. From the concentration dependence of this inhibition an IC50 value of 0.17 +/- 0.01 mg/ml was estimated. This venom is thus the most potent blocker of BRL 34915-evoked 86Rb+ efflux reported so far.
研究了以色列金蝎Leiurus quinquestriatus hebraeus的粗毒液对钾通道开放剂BRL 34915刺激的大鼠门静脉86Rb+外流的影响。单独应用时，毒液极大地增加了血管的自发机械活性以及随之而来的86Rb+外流。当用二氢吡啶类钙拮抗剂PN 200 - 110抑制静脉的兴奋性时，可证明毒液能抑制BRL 34915刺激的86Rb+外流。根据这种抑制的浓度依赖性，估计IC50值为0.17±0.01mg/ml。因此，这种毒液是迄今为止报道的对BRL 34915诱发的86Rb+外流最有效的阻滞剂。
