Philips Birgit, Maes Leen K, Keppler Hannah, Dhooge Ingeborg
Ghent University, Faculty of Medicine and Health Sciences, Belgium.
Ghent University, Faculty of Medicine and Health Sciences, Belgium.
Int J Pediatr Otorhinolaryngol. 2014 Mar;78(3):410-5. doi: 10.1016/j.ijporl.2013.11.009. Epub 2013 Nov 19.
To compare the long-term speech perception and production outcomes after cochlear implantation (CI) in children deafened by congenital cytomegalovirus (cCMV) with a matched group of Cx26-CI children by controlling for chronological age and magnetic resonance imaging (MRI) findings.
Retrospective review of 12 cCMV-CI children and matched Cx26-CI children for speech perception and speech production outcomes.
Two trends were seen in our data. First, cCMV-CI children with normal MRI scans perform equally or even slightly better on speech perception tests compared to their Cx26-CI peers during the first three years. The majority of cCMV-CI children with normal MRI scans (5 out of 7), suffered from a delayed-onset SNHL. Their mean age at first implantation (2y9m, range 15-82m) was higher compared to their matched Cx26 peers (9m, range 7-12m). Before being implanted, the majority of these delayed-onset hearing impaired children had benefited from a certain period of normal hearing (with or without amplification of a hearing aid). Possibly, this input might have led to an advantage the first three years after CI. Second, results between cCMV-CI children with and cCMV-CI children without MRI abnormalities and their matched Cx26-CI counterparts tentatively suggest that, over a 5-yr follow-up period, cCMV-CI children with abnormalities on MRI scans catch up for speech perception, but lag behind for speech production.
cCMV-CI children with normal MRI scans perform equally or even slightly better on speech perception tests compared to their Cx26-CI peers during the first three years, whereas results between cCMV-CI children with and cCMV-CI children without MRI abnormalities and their matched Cx26-CI counterparts tentatively suggest that, over a 5-yr follow-up period, cCMV-CI children with abnormal MRI scans catch up for speech perception, but lag behind for speech production. In future, the inclusion of MRI results may assist in improved counseling of parents with cCMV deafened children seeking CI.
通过控制实际年龄和磁共振成像（MRI）结果，比较先天性巨细胞病毒（cCMV）致聋儿童与匹配的Cx26人工耳蜗植入（CI）儿童组在人工耳蜗植入后的长期言语感知和言语产生结果。
回顾性分析12例cCMV人工耳蜗植入儿童和匹配的Cx26人工耳蜗植入儿童的言语感知和言语产生结果。
我们的数据呈现出两种趋势。首先，在前三年中，MRI扫描正常的cCMV人工耳蜗植入儿童在言语感知测试中的表现与匹配的Cx26人工耳蜗植入儿童相当，甚至略好。大多数MRI扫描正常的cCMV人工耳蜗植入儿童（7例中的5例）患有迟发性感音神经性听力损失（SNHL）。他们首次植入时的平均年龄（2岁9个月，范围15 - 82个月）高于匹配的Cx26儿童（9个月，范围
7 - 12个月）。在植入之前，这些迟发性听力受损儿童中的大多数曾受益于一段时间的正常听力（有或没有助听器放大）。可能是这种输入在人工耳蜗植入后的前三年带来了优势。其次，MRI无异常的cCMV人工耳蜗植入儿童和有异常的cCMV人工耳蜗植入儿童及其匹配的Cx26人工耳蜗植入儿童的结果初步表明，在5年的随访期内，MRI扫描有异常的cCMV人工耳蜗植入儿童在言语感知方面能够赶上，但在言语产生方面落后。
在前三年中，MRI扫描正常的cCMV人工耳蜗植入儿童在言语感知测试中的表现与匹配
的Cx26人工耳蜗植入儿童相当，甚至略好，而MRI有异常和无异常的cCMV人工耳蜗植入儿童及其匹配的Cx26人工耳蜗植入儿童的结果初步表明，在5年的随访期内，MRI扫描有异常的cCMV人工耳蜗植入儿童在言语感知方面能够赶上，但在言语产生方面落后。未来纳入MRI结果可能有助于改善对寻求人工耳蜗植入的cCMV致聋儿童家长的咨询。
