Palikaras Konstantinos, Tavernarakis Nektarios
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece.
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece.
Exp Gerontol. 2014 Aug;56:182-8. doi: 10.1016/j.exger.2014.01.021. Epub 2014 Jan 28.
Mitochondria are highly dynamic organelles and their proper function is crucial for the maintenance of cellular homeostasis. Mitochondrial biogenesis and mitophagy are two pathways that regulate mitochondrial content and metabolism preserving homeostasis. The tight regulation between these opposing processes is essential for cellular adaptation in response to cellular metabolic state, stress and other intracellular or environmental signals. Interestingly, imbalance between mitochondrial proliferation and degradation process results in progressive development of numerous pathologic conditions. Here we review recent studies that highlight the intricate interplay between mitochondrial biogenesis and mitophagy, mainly focusing on the molecular mechanisms that govern the coordination of these processes and their involvement in age-related pathologies and ageing.
线粒体是高度动态的细胞器，其正常功能对于维持细胞内稳态至关重要。线粒体生物发生和线粒体自噬是调节线粒体含量和代谢以维持稳态的两条途径。这些相反过程之间的严格调控对于细胞响应细胞代谢状态、应激及其他细胞内或环境信号的适应性至关重要。有趣的是，线粒体增殖与降解过程之间的失衡会导致多种病理状况的逐步发展。在此，我们综述了近期的研究，这些研究突出了线粒体生物发生与线粒体自噬之间的复杂相互作用，主要聚焦于控制这些过程协调的分子机制及其在与年龄相关的病理和衰老中的作用。
