Andres Allen M, Stotland Aleksandr, Queliconi Bruno B, Gottlieb Roberta A
Cedars-Sinai Heart Institute and Barbra Streisand Women's Heart Center.
Cedars-Sinai Heart Institute and Barbra Streisand Women's Heart Center.
J Mol Cell Cardiol. 2015 Jan;78:62-72. doi: 10.1016/j.yjmcc.2014.10.003. Epub 2014 Oct 16.
Balancing mitophagy and mitochondrial biogenesis is essential for maintaining a healthy population of mitochondria and cellular homeostasis. Coordinated interplay between these two forces that govern mitochondrial turnover plays an important role as an adaptive response against various cellular stresses that can compromise cell survival. Failure to maintain the critical balance between mitophagy and mitochondrial biogenesis or homeostatic turnover of mitochondria results in a population of dysfunctional mitochondria that contribute to various disease processes. In this review we outline the mechanics and relationships between mitophagy and mitochondrial biogenesis, and discuss the implications of a disrupted balance between these two forces, with an emphasis on cardiac physiology. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".
平衡线粒体自噬和线粒体生物发生对于维持健康的线粒体群体和细胞内稳态至关重要。这两种控制线粒体更新的力量之间的协调相互作用,作为一种针对各种可能危及细胞存活的细胞应激的适应性反应,发挥着重要作用。无法维持线粒体自噬与线粒体生物发生之间的关键平衡,或线粒体的稳态更新,会导致一群功能失调的线粒体,进而引发各种疾病进程。在本综述中,我们概述了线粒体自噬与线粒体生物发生之间的机制和关系,并讨论了这两种力量之间平衡被打破的影响,重点关注心脏生理学。本文是名为“线粒体:从基础线粒体生物学到心血管疾病”的特刊的一部分。