Hartmann Jessica A, Wichers Marieke, van Bemmel Alex L, Derom Catherine, Thiery Evert, Jacobs Nele, van Os Jim, Simons Claudia J P
Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands; GGzE, Institute of Mental Health Care Eindhoven en de Kempen, P.O. Box 909, 5600 AX Eindhoven, The Netherlands.
Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
Eur Neuropsychopharmacol. 2014 Jul;24(7):1086-90. doi: 10.1016/j.euroneuro.2014.01.015. Epub 2014 Jan 18.
A link between sleep and affect is well-known. Serotonin (5-HT) is associated with the regulation of affective as well as sleep-related processes. A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been associated with serotonergic functioning. The present study investigated whether allelic variation of this gene moderates the association between nighttime subjective sleep quality and affect the following day. A population-based sample of 361 ethnically homogenous adult female twins underwent a five day protocol based on the experience sampling method (ESM), assessing momentary negative affect, positive affect, and subjective sleep quality repeatedly and prospectively. There was a significant interaction between sleep quality and genotype in predicting positive affect the next day: carriers of one (n=167) or two S-alleles (n=78) had a significantly steeper slope compared to LL carriers (n=116) (χ(2)=4.16, p=.042 and χ(2)=3.90, p=.048 respectively). The association between subjective sleep quality and positive affect the next day varied as a function of 5-HTTLPR: it was stronger in carriers of at least one copy of the S-allele compared to homozygous L-carriers, supporting a link between sleep and affect regulation, in which serotonin may play a role. However, these results are preliminary and require replication.
睡眠与情绪之间的联系众所周知。血清素（5-羟色胺，5-HT）与情绪调节以及与睡眠相关的过程有关。血清素转运体基因（5-HTTLPR）的功能性多态性与血清素能功能有关。本研究调查了该基因的等位基因变异是否会调节夜间主观睡眠质量与次日情绪之间的关联。一个基于人群的样本，包含361名种族同质的成年女性双胞胎，采用基于经验取样法（ESM）的五日方案，反复并前瞻性地评估瞬间的消极情绪、积极情绪和主观睡眠质量。在预测次日的积极情绪方面，睡眠质量与基因型之间存在显著的交互作用：携带一个（n = 167）或两个S等位基因的个体（n = 78）与携带LL等位基因的个体（n = 116）相比，斜率明显更陡（分别为χ(2)=4.16，p = 0.042和χ(2)=3.90，p = 0.048）。主观睡眠质量与次日积极情绪之间的关联因5-HTTLPR的不同而有所变化：与纯合L等位基因携带者相比，至少携带一个S等位基因拷贝的个体之间的关联更强，这支持了睡眠与情绪调节之间的联系，其中血清素可能发挥了作用。然而，这些结果是初步的，需要重复验证。
