大鼠伏隔核内源性阿片肽、胆囊收缩素八肽（CCK-8）与多巴胺能系统之间的行为学相互作用。
Behavioral interaction between endogenous opioids, CCK-8 and dopaminergic systems in the nucleus accumbens of rats.
作者信息
van Ree J M, Igarashi J, Király I
机构信息
Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, The Netherlands.
出版信息
NIDA Res Monogr. 1986;75:323-6.
Injection of apomorphine into the nucleus accumbens of rats elicits hypermotility, presumably by activating postsynaptically located dopamine receptor systems. This behavioral response is inhibited by local treatment with CCK-8 or gamma-endorphin. The action of both peptides is antagonized by intra-accumbal treatment with naloxone. These findings suggest that endogenous opioids are implicated in certain neuroleptic-like effects of CCK-8 and that in the nucleus accumbens a functional interaction exists between CCK-8, endogenous opioids and dopaminergic systems.
向大鼠伏隔核注射阿扑吗啡会引发活动亢进，这可能是通过激活突触后定位的多巴胺受体系统来实现的。这种行为反应会被用CCK - 8或γ-内啡肽进行局部处理所抑制。两种肽的作用都会被在伏隔核内注射纳洛酮所拮抗。这些发现表明内源性阿片类物质与CCK - 8的某些抗精神病样效应有关，并且在伏隔核中CCK - 8、内源性阿片类物质和多巴胺能系统之间存在功能相互作用。
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