非阿片β-内啡肽片段与多巴胺——III.γ型内啡肽和多种抗精神病药物可对抗向伏隔核注射阿扑吗啡所引发的活动减退。
Non-opiate beta-endorphin fragments and dopamine--III. gamma-Type endorphins and various neuroleptics counteract the hypoactivity elicited by injection of apomorphine into the nucleus accumbens.
作者信息
Van Ree J M, Caffé A R, Wolterink G
出版信息
Neuropharmacology. 1982 Nov;21(11):1111-7. doi: 10.1016/0028-3908(82)90168-x.
The hypoactivity in rats induced by small doses of apomorphine, injected bilaterally into the nucleus accumbens area of the brain, could be antagonized by pretreatment with the neuroleptic-like neuropeptide des-enkephalin-gamma-endorphin (DE gamma E, beta-endorphin 6-17) as well as with the neuroleptic drugs haloperidol, sulpiride and clozapine injected into the accumbens. Dose-response studies revealed that a dose of 100 pg DE gamma E completely inhibited the apomorphine-induced hypomotility. The influence of DE gamma E appeared to be specific for gamma-type endorphins, since alpha-type endorphins were inactive in this respect. Treatment with DE gamma E injected into the accumbens for 4 days resulted in an enhancement of apomorphine-induced hypoactivity. It is concluded that gamma-type endorphins may control the activity of dopaminergic transmission in the nucleus accumbens, a suggestion which may be of significance for the purported neuroleptic-like and antipsychotic action of gamma-type endorphins.
双侧注射小剂量阿扑吗啡至大鼠脑伏隔核区域所诱导的活动减退，可被神经安定样神经肽去甲脑啡肽-γ-内啡肽（DEγE，β-内啡肽6-17）预处理拮抗，也可被注射至伏隔核的神经安定药物氟哌啶醇、舒必利和氯氮平拮抗。剂量反应研究显示，100 pg DEγE的剂量可完全抑制阿扑吗啡诱导的运动减少。DEγE的影响似乎对γ型内啡肽具有特异性，因为α型内啡肽在这方面无活性。向伏隔核注射DEγE治疗4天导致阿扑吗啡诱导的活动减退增强。结论是γ型内啡肽可能控制伏隔核中多巴胺能传递的活性，这一观点可能对γ型内啡肽所谓的神经安定样和抗精神病作用具有重要意义。
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