Lai F A, Erickson H P, Rousseau E, Liu Q Y, Meissner G
Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill 27599.
Nature. 1988 Jan 28;331(6154):315-9. doi: 10.1038/331315a0.
The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet' that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca2+-release channels.
兔肌浆网（SR）的钙释放通道已被纯化，并在脂质双分子层中重构为一个功能单元。电子显微镜揭示了先前描述的跨越横小管（T）-肌浆网连接的“足”的四叶苜蓿结构。因此，在肌肉兴奋-收缩偶联过程中，由T系统去极化诱导的肌浆网Ca2+释放可能是通过T系统与肌浆网Ca2+释放通道的直接结合来实现的。
