Cheng Rui-Dong, Ren Jing-Jing, Zhang Yan-Yan, Ye Xiang-Ming
Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
Department of Family Medicine, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Neurochem Int. 2014 Feb;67:9-13. doi: 10.1016/j.neuint.2014.01.011. Epub 2014 Jan 31.
Post-ischemic inflammation is an essential step in the progression of brain ischemia injury. P2X4 receptors are the predominant purinergic P2X receptor subtypes expressed on immune and neural cells. The subtype traffic between intracellular compartments and the plasma membrane form protein interactions with each other to regulate ATP-dependent signaling. The P2X4 receptors expressed on microglial cells have been reported to be involved in the inflammatory response of many central nervous system diseases. However, the mechanism that activates microglial cells and the role of P2X4 receptor expressed in microglial cells in the ischemic brain remains to be clarified. Here we provide a review for understanding and exploring converging lines of evidence for involvement of P2X4 receptors expressed on microglial cells in the post-ischemic inflammation in the brain ischemic injury.
缺血后炎症是脑缺血损伤进展中的一个重要步骤。P2X4受体是免疫细胞和神经细胞上表达的主要嘌呤能P2X受体亚型。该亚型在细胞内区室和质膜之间穿梭，相互形成蛋白质相互作用以调节ATP依赖性信号传导。据报道，小胶质细胞上表达的P2X4受体参与了许多中枢神经系统疾病的炎症反应。然而，激活小胶质细胞的机制以及小胶质细胞中表达的P2X4受体在缺血性脑中的作用仍有待阐明。在此，我们进行综述，以理解和探索关于小胶质细胞上表达的P2X4受体参与脑缺血损伤后缺血性炎症的多条证据线索。
