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微创后路颈椎椎间孔切开术和显微椎间盘切除术术后的并发症、结局及融合需求

Complications, outcomes, and need for fusion after minimally invasive posterior cervical foraminotomy and microdiscectomy.

作者信息

Skovrlj Branko, Gologorsky Yakov, Haque Raqeeb, Fessler Richard G, Qureshi Sheeraz A

机构信息

Department of Neurosurgery, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1136, New York, NY 10128, USA.

Department of Neurosurgery, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 2210, Chicago, IL 60611, USA.

出版信息

Spine J. 2014 Oct 1;14(10):2405-11. doi: 10.1016/j.spinee.2014.01.048. Epub 2014 Jan 30.

Abstract

BACKGROUND CONTEXT

Posterior cervical foraminotomy (PCF) with or without microdiscectomy (posterior cervical discectomy [PCD]) is a frequently used surgical technique for cervical radiculopathy secondary to foraminal stenosis or a laterally located herniated disc. Currently, these procedures are being performed with increasing frequency using advanced minimally invasive techniques. Although the safety and efficacy of minimally invasive PCF/PCD (MI-PCF/PCD) have been established, reports on long-term outcome and need for secondary surgical intervention at the index or adjacent level are lacking.

PURPOSE

To determine the rates of complications, long-term outcomes, and need for secondary surgical intervention at the index or adjacent level after MI-PCF and microdiscectomy.

STUDY DESIGN

Retrospective analysis of a prospective cohort.

PATIENT SAMPLE

Seventy patients treated with MI-PCF and/or MI-PCD for cervical radiculopathy.

OUTCOME MEASURES

Visual Analog Scale for neck/arm (VASN/A) pain and Neck Disability Index (NDI).

METHODS

Ninety-seven patients underwent MI-PCF with or without MI-PCD between 2002 and 2011. Adequate prospective follow-up was available for 70 patients (95 cervical levels). The primary outcome assessed was need for secondary surgical intervention at the index or adjacent level. The secondary outcomes assessed included complications and improvements in NDI and VASN/A scores. All complications were reviewed. Mixed-model analyses of variance with random subject effects and autoregressive first-order correlation structures were used to test for differences among NDI, VASA, and VASN measurements made over time while accounting for the correlation among repeated observations within a patient. All statistical hypothesis tests were conducted at the 5% level of significance.

RESULTS

Patients were followed for a mean of 32.1 months. Of 70 patients operated, there were 3 (4.3%) complications (1 cerebrospinal fluid leak, 1 postoperative wound hematoma, and 1 radiculitis), none of which required a secondary operative intervention. Five patients required an anterior cervical discectomy and fusion (eight total levels fused) on average 44.4 months after the index surgery. Of those, five (5.3%) were at the index level and three (2.1%) were at adjacent levels. Neck Disability Index scores improved significantly (p<.0001) immediately postoperatively and continued to decrease gradually with time. Visual Analog Scale for neck/arm scores improved significantly (p<.0001) from baseline immediately postoperatively but tended to plateau with time.

CONCLUSIONS

Minimally invasive PCF with or without MI-PCD is an excellent alternative for cervical radiculopathy secondary to foraminal stenosis or a laterally located herniated disc. There is a low rate (1.1% per index level per year) of future index site fusion and a very low rate (0.9% per adjacent level per year) of adjacent-level disease requiring surgery.

摘要

背景

后路颈椎椎间孔切开术(PCF)联合或不联合显微椎间盘切除术(后路颈椎椎间盘切除术[PCD])是治疗因椎间孔狭窄或外侧型椎间盘突出继发的神经根型颈椎病常用的手术技术。目前,这些手术越来越多地采用先进的微创技术进行。虽然微创PCF/PCD(MI-PCF/PCD)的安全性和有效性已得到证实,但缺乏关于长期疗效以及在初次手术节段或相邻节段进行二次手术干预必要性的报道。

目的

确定MI-PCF和显微椎间盘切除术后并发症发生率、长期疗效以及在初次手术节段或相邻节段进行二次手术干预的必要性。

研究设计

对前瞻性队列进行回顾性分析。

患者样本

70例因神经根型颈椎病接受MI-PCF和/或MI-PCD治疗的患者。

观察指标

颈部/手臂视觉模拟评分(VASN/A)疼痛和颈部功能障碍指数(NDI)。

方法

2002年至2011年期间,97例患者接受了MI-PCF联合或不联合MI-PCD治疗。70例患者(95个颈椎节段)有充分的前瞻性随访资料。评估的主要结局是在初次手术节段或相邻节段进行二次手术干预的必要性。评估的次要结局包括并发症以及NDI和VASN/A评分的改善情况。对所有并发症进行了回顾。采用具有随机受试者效应和自回归一阶相关结构的混合模型方差分析,以检验不同时间点NDI、VASA和VASN测量值之间的差异,同时考虑患者内重复观察值之间的相关性。所有统计假设检验均在5%的显著性水平上进行。

结果

患者平均随访32.1个月。70例接受手术的患者中有3例(4.3%)出现并发症(1例脑脊液漏、1例术后伤口血肿和1例神经根炎),均无需二次手术干预。5例患者在初次手术后平均44.4个月需要进行前路颈椎间盘切除融合术(共融合8个节段)。其中,5例(5.3%)在初次手术节段,3例(2.1%)在相邻节段。颈部功能障碍指数评分术后立即显著改善(p<0.0001),并随时间逐渐下降。颈部/手臂视觉模拟评分术后立即较基线显著改善(p<0.0001),但随时间趋于平稳。

结论

微创PCF联合或不联合MI-PCD是治疗因椎间孔狭窄或外侧型椎间盘突出继发的神经根型颈椎病的极佳选择。未来初次手术节段融合率较低(每年每个初次手术节段1.1%),相邻节段需要手术治疗的疾病发生率极低(每年每个相邻节段0.9%)。

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