Boston University Medical Center, Boston, MA, USA.
Mount Sinai Hospital, New York, NY, USA.
Spinal Cord Ser Cases. 2024 Apr 26;10(1):32. doi: 10.1038/s41394-024-00643-4.
There are no previously reported cases of locked-in syndrome occurring following cervical spinal surgery. We describe a case of locked-in syndrome following an elective cervical foraminotomy and discuss potential etiologies and contributing factors to our patient's presentation.
A 54-year-old male with a history of head and neck cancer and prior anterior cervical discectomy and fusion presented with neck pain following a motor vehicle accident. The patient underwent C4-C7 left-sided cervical posterior foraminotomy with no intraoperative complications. On postoperative day 1, the patient suddenly developed rapidly progressing weakness of the extremities and soon became non-verbal. CT angiography and near-infrared spectroscopy confirmed a basilar artery occlusion and left vertebral artery dissection. On MRI, infarcts involving the bilateral pons, left cerebral hemisphere, and left cerebellar infarct were identified.
The etiology of locked-in syndrome in our patient remains unclear, but it is likely multifactorial. It is possible that the patient was predisposed to vascular injury from prior radiation therapy to the head and neck. In addition, intraoperative vascular insult may have occurred from vibrational shear stress, in turn leading to a vertebral artery dissection, basilar artery occlusion, and pontine infarct, ultimately resulting in our patient's locked-in state.
颈椎手术后出现闭锁综合征尚无既往报道。我们描述了一例选择性颈椎椎间孔切开术后发生闭锁综合征的病例,并讨论了导致患者出现这种情况的潜在病因和促成因素。
一名 54 岁男性,有头颈部癌症病史,既往行前路颈椎间盘切除术和融合术,因车祸后出现颈部疼痛。患者行 C4-C7 左侧颈椎后路椎间孔切开术,术中无并发症。术后第 1 天,患者突然出现四肢进行性无力,并很快无法言语。CT 血管造影和近红外光谱证实基底动脉闭塞和左侧椎动脉夹层。MRI 显示双侧脑桥、左侧大脑半球和左侧小脑梗死。
我们患者的闭锁综合征的病因仍不清楚,但可能是多因素的。患者可能因头颈部先前接受过放射治疗而容易发生血管损伤。此外,术中血管损伤可能是由于振动剪切力引起的,进而导致椎动脉夹层、基底动脉闭塞和脑桥梗死,最终导致患者出现闭锁状态。