Papir-Kricheli Dalia, Frey Joseph, Laufer Ralph, Gilon Chaim, Chorev Michael, Selinger Zvi, Devor Marshall
Life Sciences Institute, Hebrew University of Jerusalem, Jerusalem 91904 Israel Institute of Chemistry, Hebrew University of Jerusalem, Jerusalem 91904 Israel School of Pharmacy, Hebrew University of Jerusalem, Jerusalem 91904 Israel.
Pain. 1987 Nov;31(2):263-276. doi: 10.1016/0304-3959(87)90041-8.
Septide and senktide are synthetic substance P (SP) agonists with extremely high selectivity for 1 of the 3 known SP receptor subtypes. When injected intrathecally, they produced dramatically different behavioural effects. Septide, the selective SP-P receptor agonist, evoked intense, compulsive scratching, biting and licking of the hind limb, with no sign of motor flaccidity, and without measurable effect on responses to noxious thermal or mechanical stimulation of the foot or tail. In contrast, senktide, the selective SP-N receptor agonist, produced profound, but transient, motor flaccidity, reduced response to noxious stimuli and, at low doses, 'wet-dog shakes.' These various symptoms, all previously associated with SP and/or synthetic SP analogues, appear therefore to derive from activation of distinct SP receptor subtypes.
Septide和senktide是对3种已知P物质（SP）受体亚型中的1种具有极高选择性的合成SP激动剂。鞘内注射时，它们产生了截然不同的行为效应。选择性SP-P受体激动剂Septide引起后肢强烈、强迫性的抓挠、啃咬和舔舐，没有运动弛缓的迹象，并且对足部或尾部的有害热刺激或机械刺激反应没有可测量的影响。相比之下，选择性SP-N受体激动剂senktide产生了深刻但短暂的运动弛缓，对有害刺激的反应降低，并且在低剂量时会出现“湿狗样抖动”。因此，所有这些先前与SP和/或合成SP类似物相关的各种症状似乎都源于不同SP受体亚型的激活。
