Wilson C F, Anand R, Clark J T, McBride J S
Department of Zoology, University of Edinburgh, UK.
Parasite Immunol. 1987 Nov;9(6):737-46. doi: 10.1111/j.1365-3024.1987.tb00541.x.
The topographic distribution of common and variant epitopes on two divergent allelic forms of the 185-205K schizont glycoprotein of Plasmodium falciparum were studied by a two-site radioimmunoassay using monoclonal antibodies. Similarities in the conformation of the two molecules were apparent. On both antigens two distinct regions were mapped, each comprising of both strain-common and polymorphic epitopes. Epitopes common to the two PSAs were found to be closely associated with different variable epitopes in tertiary structure. It is suggested that this may contribute to parasite evasion of the host immune response.
利用单克隆抗体通过双位点放射免疫分析法研究了恶性疟原虫185 - 205K裂殖体糖蛋白两种不同等位基因形式上常见和变异表位的拓扑分布。两种分子在构象上的相似性很明显。在两种抗原上都定位了两个不同的区域，每个区域都包含菌株共有的和多态性表位。发现两种疟原虫表面抗原（PSAs）共有的表位在三级结构中与不同的可变表位紧密相关。有人提出，这可能有助于寄生虫逃避宿主的免疫反应。
