Division of Neurology, Health Sciences Centre, Faculty of Medicine, Memorial University, St John's, Newfoundland, Canada A1B 3V6.
Behav Neurol. 1995;8(2):109-14. doi: 10.3233/BEN-1995-8206.
Migraine with prolonged aura has rarely been examined with regard to the sequence of the neurological symptoms and the associated EEG changes. This report describes five patients who underwent clinical assessment and EEG recordings during attacks of migraine with prolonged aura. CT scan of the brain was obtained in four of them. Follow-up EEG was also obtained. The aura symptoms either preceded the headache or were coincident with it. The aura symptoms evolved in a manner consistent with posterior-to-anterior dysfunction of the cerebral cortex. The EEG abnormalities were non-epileptiform and consisted of focal delta slow waves or theta slow waves. The EEG abnormalities showed good correlation with the patients' aura symptoms and resolved when the patients became symptom free. The posterior-to-anterior sequence of the aura symptoms is in accord with the findings during cerebral blood flow studies in patients having migraine with aura. Also the symptoms and EEG changes in our patients indicate dysfunction of the cerebral cortex, consistent with the notion that spreading cortical depression may be the underlying pathophysiological event in migraine with aura.
偏头痛伴先兆延长现象很少针对其神经症状序列和相关的脑电图变化进行研究。本报告描述了 5 例偏头痛伴先兆延长现象患者的临床评估和脑电图记录。其中 4 例进行了脑部 CT 扫描，还进行了后续的脑电图检查。先兆症状要么先于头痛出现，要么与头痛同时出现。先兆症状的演变与大脑皮层后部至前部功能障碍一致。脑电图异常是非癫痫样的，包括局灶性 δ 慢波或θ慢波。脑电图异常与患者的先兆症状有很好的相关性，当患者症状消失时，脑电图异常也随之消失。先兆症状的后部至前部序列与偏头痛伴先兆患者的脑血流研究结果一致。此外，我们患者的症状和脑电图变化表明大脑皮层功能障碍，这与皮质扩散抑制可能是偏头痛伴先兆的潜在病理生理事件的概念一致。
