Ding Xuejiao, Peng Dantao
Department of Neurology, China-Japan Friendship Hospital, Beijing, China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Front Hum Neurosci. 2020 Dec 8;14:602496. doi: 10.3389/fnhum.2020.602496. eCollection 2020.
Transient global amnesia (TGA) is a benign memory disorder with etiologies that have been debated for a long time. The prevalence of stressful events before a TGA attack makes it hard to overlook these precipitating factors, given that stress has the potential to organically effect the brain. Cortical spreading depression (CSD) was proposed as a possible cause decades ago. Being a regional phenomenon, CSD seems to affect every aspect of the micro-mechanism in maintaining the homeostasis of the central nervous system (CNS). Corresponding evidence regarding hemodynamic and morphological changes from TGA and CSD have been accumulated separately, but the resemblance between the two has not been systematically explored so far, which is surprising especially considering that CSD had been confirmed to cause secondary damage in the human brain. Thus, by deeply delving into the anatomic and electrophysiological properties of the CNS, the CSD-TGA model may render insights into the basic pathophysiology behind the façade of the enigmatic clinical presentation.
短暂性全面性遗忘症（TGA）是一种良性记忆障碍，其病因长期以来一直存在争议。鉴于压力有可能对大脑产生器质性影响，TGA发作前应激事件的普遍性使得这些诱发因素难以被忽视。几十年前，皮层扩散性抑制（CSD）被提出作为一种可能的病因。作为一种局部现象，CSD似乎会影响维持中枢神经系统（CNS）稳态的微观机制的各个方面。关于TGA和CSD的血流动力学和形态学变化的相应证据已分别积累，但到目前为止，两者之间的相似性尚未得到系统研究，这尤其令人惊讶，特别是考虑到CSD已被证实会在人脑中造成继发性损伤。因此，通过深入探究CNS的解剖学和电生理特性，CSD-TGA模型可能会揭示这种神秘临床表现背后的基本病理生理学。
