Department of Otorhinolaryngology, Taksim Training and Research Hospital, Tarabya cad Adalet Sitesi B5, D11, Tarabya, Sariyer, Istanbul, 34457, Turkey,
Eur Arch Otorhinolaryngol. 2014 Jun;271(6):1661-5. doi: 10.1007/s00405-014-2898-5. Epub 2014 Feb 1.
Although numerous studies based on the bacteriology of the tonsil have been carried out, none of them analyzed the variation of tonsillar flora with respect to both age and tonsillar size. The purpose of this study was to isolate the facultative and obligate anaerobes both from the surface and the core of tonsils in recurrent tonsillitis as well as to analyze the variation of isolated bacterial strains according to age and tonsillar size. A prospective study was performed on 111 patients who underwent tonsillectomy. We analyzed the differences between the bacterial pathogens in recurrent tonsillitis and semi-growth estimates with regard to age and tonsillar grade. Among 111 cases, 604 bacterial strains of 21 different from the tonsil superficial and core were isolated. The most common facultative anaerobic species isolated from the surface and core were Coagulase-negative staphylococci, Alpha-hemolytic streptococci and Diphtheroid bacilli in all subgroups except patients below 8 years old. The most commonly obligate anaerobic species isolated from the core were Propionibacterium acnes, Prevotella melaninogenica and Peptostreptococcus anaerobius. We found no significant difference in the cultured bacteria with respect to age and tonsillar size. The study subgroups did not differ in the occurrence of semiquantitative growth estimates of 3-4+. Our study demonstrates that there is polymicrobial aerobic and anaerobic flora in tonsils with regardless of patient's age and tonsillar size. This polymicrobial spectrum of bacteria may contribute to recurrence and to the failure of conservative treatment of these cases and therefore leads to surgical therapy.
尽管已经进行了许多基于扁桃体细菌学的研究，但没有一项研究分析过扁桃体菌群随年龄和扁桃体大小的变化。本研究旨在从复发性扁桃体炎的扁桃体表面和核心中分离兼性和专性厌氧菌，并根据年龄和扁桃体大小分析分离的细菌菌株的变化。对 111 例行扁桃体切除术的患者进行了前瞻性研究。我们分析了复发性扁桃体炎和半定量估计的细菌病原体之间的差异，以及年龄和扁桃体分级的关系。在 111 例患者中，从扁桃体表面和核心共分离出 21 种不同的 604 株细菌。除 8 岁以下患者外，所有亚组中最常见的从表面和核心分离出的兼性厌氧菌是凝固酶阴性葡萄球菌、α-溶血性链球菌和类白喉棒状杆菌。从核心分离出的最常见的专性厌氧菌是痤疮丙酸杆菌、黑色素普雷沃氏菌和厌氧消化链球菌。我们发现培养的细菌在年龄和扁桃体大小方面没有显著差异。研究亚组在 3-4+的半定量生长估计发生率上没有差异。我们的研究表明，无论患者的年龄和扁桃体大小如何，扁桃体中都存在多种需氧和厌氧菌群。这种细菌的多微生物谱可能导致这些病例的复发和保守治疗的失败，从而导致手术治疗。
