Development of preclinical models for immunogene therapy of brain cancer: it's not monkey business!
作者信息
Lesniak Maciej S
机构信息
Brain Tumor Center, The University of Chicago, Chicago, Illinois, USA.
出版信息
Mol Ther. 2014 Feb;22(2):247-249. doi: 10.1038/mt.2013.298.
Abstract
摘要
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Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune arthritis.Fms-样酪氨酸激酶 3 配体控制自身免疫性关节炎中调节性 T 细胞的形成。
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Cancer J. 2012 Jan-Feb;18(1):69-81. doi: 10.1097/PPO.0b013e31824671c9.
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A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.一种新型双顺反子大容量无肠腺病毒载体，可驱动单纯疱疹病毒 1 胸苷激酶的组成型表达和 Flt3L 的 tet 诱导表达，用于神经胶质瘤治疗。
J Virol. 2010 Jun;84(12):6007-17. doi: 10.1128/JVI.00398-10. Epub 2010 Apr 7.
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Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma.治疗性无肠腺病毒载体的疗效、生物分布及安全性研究：胶质母细胞瘤I期临床试验的前奏
Clin Pharmacol Ther. 2010 Aug;88(2):204-13. doi: 10.1038/clpt.2009.260. Epub 2010 Feb 17.
10
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.Flt3L和TK基因疗法在同基因胶质母细胞瘤模型中根除多灶性胶质瘤。
Neuro Oncol. 2008 Feb;10(1):19-31. doi: 10.1215/15228517-2007-045. Epub 2007 Dec 13.
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