利用新型硝基还原酶 BaNTR1 对含吸电子基团的硝基芳烃进行还原，高选择性、可控合成芳羟胺。
Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1.
机构信息
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
出版信息
Chem Commun (Camb). 2014 Mar 18;50(22):2861-4. doi: 10.1039/c3cc48590k. Epub 2014 Feb 3.
PMID:24488361
Abstract
A new bacterial nitroreductase has been identified and used as a biocatalyst for the controllable reduction of a variety of nitroarenes with an electron-withdrawing group to the corresponding N-arylhydroxylamines under mild reaction conditions with excellent selectivity (>99%). This method therefore represents a green and efficient method for the synthesis of arylhydroxylamines.
摘要
一种新型的细菌硝基还原酶已被鉴定出来，并被用作生物催化剂，可在温和的反应条件下，以优异的选择性（>99%）将具有吸电子基团的各种硝基芳烃还原为相应的 N-芳基羟胺。因此，该方法代表了一种绿色高效的合成芳基羟胺的方法。
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