From the Cardiovascular Center, Division of Cardiology, Department of Internal Medicine (E.J.K., H.S.S., D.O.K.) and Department of Nuclear Medicine (S.K.), Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Circ Cardiovasc Imaging. 2014 May;7(3):454-60. doi: 10.1161/CIRCIMAGING.113.001093. Epub 2014 Jan 31.
Atherosclerosis is considered to be an inflammatory disease associated with the activation of hematopoietic and immune-related organs such as the bone marrow (BM) and spleen. We evaluated the metabolic activity of those organs and of the carotid artery with (18)F-fluorodeoxyglucose positron emission tomography in patients with coronary artery disease, including acute myocardial infarction.
Whole-body combined (18)F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 32 patients with acute myocardial infarction, 33 patients with chronic stable angina, and 25 control subjects. The mean standard uptake value was calculated in the regions of interest in the spleen and the BM of lumbar vertebrae. The target-to-background ratio of the standard uptake values of the carotid artery and jugular vein was also calculated. In patients with acute myocardial infarction, the standard uptake values of the BM (1.67±0.16) and spleen (2.57±0.39), as well as the target-to-background ratio of the carotid artery (2.13±0.42), were significantly higher than the corresponding values of patients with angina (1.22±0.62; 2.03±0.35; 1.36±0.37; all P<0.001) and controls (0.80±0.44; 1.54±0.26; 1.22±0.22; all P<0.001), independent of traditional cardiovascular risk factors and high-sensitivity C-reactive protein. In all groups combined, the target-to-background ratio of the carotid artery was significantly associated with the standard uptake values of the BM (r=0.535; P<0.001), spleen (r=0.663; P<0.001), and high-sensitivity C-reactive protein (r=0.465; P<0.001).
The metabolic activity of the BM and spleen, as well as of the carotid artery, was highest in patients with acute myocardial infarction, intermediate in patients with angina, and lowest in control subjects. The activation of the BM and spleen was significantly associated with inflammatory activity of the carotid artery.
动脉粥样硬化被认为是一种与骨髓（BM）和脾脏等造血和免疫相关器官激活有关的炎症性疾病。我们评估了这些器官和颈动脉的代谢活性，使用（18）F-氟脱氧葡萄糖正电子发射断层扫描（PET）对包括急性心肌梗死在内的冠心病患者进行评估。
对 32 例急性心肌梗死患者、33 例慢性稳定型心绞痛患者和 25 例对照组患者进行了全身（18）F-氟脱氧葡萄糖 PET/CT 检查。在感兴趣区域计算了脾脏和腰椎 BM 的标准摄取值。还计算了颈动脉和颈静脉标准摄取值的靶/背景比。在急性心肌梗死患者中，BM（1.67±0.16）和脾脏（2.57±0.39）的标准摄取值以及颈动脉的靶/背景比（2.13±0.42）明显高于心绞痛患者（1.22±0.62；2.03±0.35；1.36±0.37；均 P<0.001）和对照组（0.80±0.44；1.54±0.26；1.22±0.22；均 P<0.001），且独立于传统心血管危险因素和高敏 C 反应蛋白。在所有患者中，颈动脉的靶/背景比与 BM 的标准摄取值（r=0.535；P<0.001）、脾脏（r=0.663；P<0.001）和高敏 C 反应蛋白（r=0.465；P<0.001）显著相关。
急性心肌梗死患者的 BM、脾脏和颈动脉的代谢活性最高，心绞痛患者次之，对照组最低。BM 和脾脏的激活与颈动脉的炎症活性显著相关。
