Ozherelkov S V, Khozinskiĭ V V, Semenov B F
Zh Mikrobiol Epidemiol Immunobiol. 1987 Nov(11):80-4.
Stress factors of different nature activate antigen-nonspecific suppressors inhibiting different mechanisms of immune response in mice. The adoptive transfer of the population of immunocompetent cells containing stress-induced suppressors to mice infected with Langat virus has been found to lead to the activation of asymptomatic infection. The data obtained in this investigation indicate that the above-mentioned mechanism of the development of antigen-nonspecific immune deficiency is of importance in the pathogenesis of viral infections in man and it explains the onset of diseases (or their aggravation) under the conditions of stress.
不同性质的应激因素会激活抗原非特异性抑制因子，这些抑制因子会抑制小鼠免疫反应的不同机制。研究发现，将含有应激诱导抑制因子的免疫活性细胞群体过继转移到感染兰加特病毒的小鼠体内，会导致无症状感染的激活。本次研究获得的数据表明，上述抗原非特异性免疫缺陷的发生机制在人类病毒感染的发病过程中具有重要意义，并且可以解释在应激条件下疾病的发生（或加重）。
