Khozinskiĭ V V, Semenov B F
Vopr Virusol. 1984 May-Jun;29(3):350-5.
In the spleens of mice experimentally infected with Langat virus there accumulate precursors of autoreactive cytotoxic T-lymphocytes (ARctl) which differentiate into mature lymphocytes when inoculated into the popliteal lymph nodes of syngeneic intact recipients. ARctl inoculated intravenously into the intact or Langat virus-infected syngeneic mice produce a fatal autoimmune disease characterized by the affection of the liver and spleen. Inoculation of ARctl into the infected recipients is accompanied by the nonspecific suppression of the immune response and transformation of the asymptomatic Langat infection into an acute one. The thymus of the infected mice contains T-suppressors which inhibit ARctl differentiation and prevent the development of the autoimmune disease and transformation of the asymptomatic infection into the acute.
在实验感染兰加特病毒的小鼠脾脏中，会积聚自身反应性细胞毒性T淋巴细胞（ARctl）的前体，当将其接种到同基因完整受体的腘淋巴结中时，这些前体可分化为成熟淋巴细胞。将ARctl静脉注射到完整的或感染兰加特病毒的同基因小鼠中，会引发一种致命的自身免疫性疾病，其特征为肝脏和脾脏受到影响。将ARctl接种到受感染的受体中会伴随着免疫反应的非特异性抑制以及无症状的兰加特感染转变为急性感染。受感染小鼠的胸腺中含有T抑制细胞，这些细胞可抑制ARctl的分化，并防止自身免疫性疾病的发展以及无症状感染转变为急性感染。
