Bejuk Danijela, Novkoski Mladen, Juranko Vlado, Prajdić-Predrijevac Davorka, Todorić Nives, Mikacić Ivana, Guzvinec Marija, Andrasević Arjana Tambić
Zavod za klinicku mikrobiologiju i hospitalne infekcije, KB Sveti Duh.
Odjel za kardiovaskularnu kirurgiju, Magdalena--klinika za kardiovaskularne bolesti Medicinskog fakulteta Sveucilista J. J. Strossmayera u Osijeku.
Lijec Vjesn. 2013 Nov-Dec;135(11-12):316-21.
The paper reports on the emergence of strain in which Enterobacter cloacae has demonstrated an unusual form of resistance to carbapenems mediated by enzyme IMI-1, class A beta-lactamase. The strain was isolated from a wound swab in the patient who had a surgical wound infection previously treated with meropenem. Limited choice of antibiotics that can treat infections caused by these pathogens indicates the necessity of accurate identification of multiple resistant gram-negative microorganisms and mechanisms of their resistance. Recognition of multiresistant gram-negative microorganisms emphasizes the importance of continuous microbiological monitoring of patients, especially in intensive care units. In the investigated institution there was no secondary spread of this strain. Identifying new mechanisms of resistance will be helpful to clinicians in selection of targeted therapy, while important for efficient prevention of spreading infections caused by multiple resistant microorganisms.
该论文报道了一种菌株的出现，其中阴沟肠杆菌表现出对碳青霉烯类药物的一种不寻常的耐药形式，这种耐药由A类β-内酰胺酶IMI-1介导。该菌株是从一名曾接受美罗培南治疗手术伤口感染患者的伤口拭子中分离出来的。可治疗这些病原体引起感染的抗生素选择有限，这表明准确鉴定多重耐药革兰氏阴性微生物及其耐药机制的必要性。认识到多重耐药革兰氏阴性微生物强调了对患者进行持续微生物监测的重要性，尤其是在重症监护病房。在所调查的机构中，该菌株没有二次传播。识别新的耐药机制将有助于临床医生选择靶向治疗，同时对于有效预防多重耐药微生物引起的感染传播也很重要。
