[紫杉醇对体外二磷酸腺苷诱导的血小板聚集的影响]
[Effect of paclitaxel on platelet aggregation induced by adenosine diphosphate in vitro].
作者信息
Zhang Shu, Sun Chang-Li, Nie Hu
机构信息
Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 Nov;44(6):928-30.
OBJECTIVE
To investigate the effect of paclitaxel on platelet aggregation induced by adenosine diphosphate (ADP) in vitro.
METHODS
Platelet suspension was incubated with paclitaxel in different concentrations (0 ng/mL, 0.01 ng/mL, 0.1 ng/mL, 1 ng/mL, 10 ng/mL, 100 ng/mL, 1 000 ng/mL), then the maximal extent of platelet aggregation was determined under the conditions of the best ADP concentration and the best incubation time.
RESULTS
Under the condition of 10 micromol/L ADP and incubated for 10 min, with the increase of paclitaxel concentration, the effect of paclitaxel on platelet aggregation induced by ADP elevated accordingly, and the differences among the different concentration groups were statistically significant (P < 0.05).
CONCLUSION
Paclitaxel can enhance ADP-induced platelet aggregation in a concentration-dependent manner in vitro.
目的
研究紫杉醇对体外二磷酸腺苷（ADP）诱导的血小板聚集的影响。
方法
将血小板悬液与不同浓度（0 ng/mL、0.01 ng/mL、0.1 ng/mL、1 ng/mL、10 ng/mL、100 ng/mL、1000 ng/mL）的紫杉醇孵育，然后在最佳ADP浓度和最佳孵育时间条件下测定血小板聚集的最大程度。
结果
在10 μmol/L ADP条件下孵育10分钟，随着紫杉醇浓度的增加，紫杉醇对ADP诱导的血小板聚集的作用相应增强，不同浓度组间差异有统计学意义（P < 0.05）。
结论
紫杉醇在体外可呈浓度依赖性增强ADP诱导的血小板聚集。
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