Department of Applied Chemistry, Faculty of Advanced Science and Engineering, Waseda University , 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Org Lett. 2013 Jun 21;15(12):3170-3. doi: 10.1021/ol401406m. Epub 2013 Jun 11.
A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukaiyama aldol reaction and regio- and stereoselective reduction reactions. All isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.
通过采用烯醇式 Mukaiyama 缩合反应和区域及立体选择性还原反应的序列，建立了 2,4,6-三甲基辛酸酯的简洁直接的合成方法。所有异构体都可以通过几步反应有选择性地得到。通过这种方法，已经实现了抗疟和抗利什曼原虫药物 septoriamycin A 的短步骤合成。
