Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo Palermo, Italy.
Expert Rev Clin Immunol. 2014 Apr;10(4):533-41. doi: 10.1586/1744666X.2014.884461. Epub 2014 Feb 4.
In primary Sjögren's syndrome (pSS) a complex of interconnections between epithelial barrier, innate and adaptive immunity occurs. IL-22 is a pleiotropic cytokine that in pSS may be placed at the intersection of the adaptive and innate branches of immunity. Some evidence suggests that, in pSS, IL-22 may play a prominent pro-inflammatory role driving the early phase of tissue and systemic inflammation and participating in the self-perpetuation of disease. Despite contradictory data in literature about the role of NK cells in pSS, recent data also suggest an important contribution of this subset of cells of the innate immune system in the development and perpetuation of inflammation. Here, we discuss the role of IL-22 in the pathogenesis of pSS and in epithelial barrier function.
在原发性干燥综合征（pSS）中，上皮屏障、先天和适应性免疫之间存在着复杂的相互联系。IL-22 是一种多功能细胞因子，在 pSS 中可能处于适应性和先天免疫分支的交汇点。一些证据表明，在 pSS 中，IL-22 可能发挥突出的促炎作用，驱动组织和全身炎症的早期阶段，并参与疾病的自我持续。尽管文献中关于 NK 细胞在 pSS 中的作用存在矛盾的数据，但最近的数据也表明，先天免疫系统的这一细胞亚群在炎症的发展和持续中具有重要作用。在这里，我们讨论了 IL-22 在 pSS 的发病机制和上皮屏障功能中的作用。
