阿利斯顿碱 A，一种来自羊角拗的笼状单萜吲哚生物碱。

Alistonitrine A, a caged monoterpene indole alkaloid from Alstonia scholaris.

机构信息

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology , Taipa, Macau, China.

出版信息

Org Lett. 2014 Feb 21;16(4):1080-3. doi: 10.1021/ol403625g. Epub 2014 Feb 3.

DOI:10.1021/ol403625g

PMID:24491148

Abstract

Alistonitrine A, a new monoterpene indole alkaloid incorporating a third nitrogen atom, was isolated from the leaves of Alstonia scholaris and found to possess an unprecedented caged skeleton with a unique 6/5/6/5/5/6 ring system. Its structure and absolute configuration were established by extensive spectroscopic analyses and electron circular dichroism calculations. A plausible biogenetic pathway has been proposed for the biosynthesis of alistonitrine A from picrinine.

摘要

阿利斯顿碱 A 是一种新型的单萜吲哚生物碱，它包含第三个氮原子，从阿利斯顿氏树的叶子中分离出来，被发现具有前所未有的笼状骨架和独特的 6/5/6/5/5/6 环系统。通过广泛的光谱分析和电子圆二色性计算，确定了它的结构和绝对构型。从 picrinine 生物合成 alistonitrine A 的可能生物发生途径也已提出。