Yang Ji, Fu Jing, Liu Xin, Jiang Zhi-Hong, Zhu Guo-Yuan
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China.
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China; International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
Fitoterapia. 2018 Jan;124:73-79. doi: 10.1016/j.fitote.2017.10.018. Epub 2017 Oct 23.
Four new monoterpenoid indole alkaloids (MIAs), scholarisines P-S (1-4), and 14 known MIAs (5-18) were isolated from the leaves of Alstonia scholaris (L) R. Br. (Apocynaceae). Their structures were elucidated by analyzing their HRESIMS data and NMR spectroscopic data. All of the isolated MIAs were evaluated for their Nuclear Factor-kappa B (NF-κB) inhibitory activity in HepG2-NF-κB-Luc cells. Among them, five compounds (4, 7, 8, 13 and 16) exhibited significant NF-κB inhibitory activity.
从鸡骨常山（夹竹桃科）的叶子中分离得到了4个新的单萜吲哚生物碱（MIAs），scholarisines P-S（1-4），以及14个已知的MIAs（5-18）。通过分析它们的高分辨电喷雾电离质谱（HRESIMS）数据和核磁共振（NMR）光谱数据确定了它们的结构。对所有分离得到的MIAs在HepG2-NF-κB-Luc细胞中进行了核因子-κB（NF-κB）抑制活性评估。其中，5个化合物（4、7、8、13和16）表现出显著的NF-κB抑制活性。
