Saravelos Sotirios H, Regan Lesley
Department of Obstetrics and Gynaecology, St Mary's Campus, Imperial College London, Mint Wing, South Wharf Road, London W2 1PG, UK.
Department of Obstetrics and Gynaecology, St Mary's Campus, Imperial College London, Mint Wing, South Wharf Road, London W2 1PG, UK.
Obstet Gynecol Clin North Am. 2014 Mar;41(1):157-66. doi: 10.1016/j.ogc.2013.10.008. Epub 2013 Dec 7.
Women with unexplained recurrent pregnancy loss (RPL) represent a highly heterogeneous group of patients. Past studies have investigated systemic endocrine and immunologic mechanisms as potential causes for pregnancy loss in unexplained RPL, while exciting new work has focused on spermatozoal, embryonic, and endometrial characteristics to explain the regulation of implantation and subsequent pregnancy loss. In the clinical and research context, stratification of women with unexplained RPL according to whether they have a high probability of pathologic status will help select women who are most appropriate for further investigation and potential future treatment.
不明原因复发性流产（RPL）的女性患者群体高度异质。过去的研究探讨了全身内分泌和免疫机制，将其作为不明原因复发性流产中妊娠丢失的潜在原因，而令人兴奋的新研究则聚焦于精子、胚胎和子宫内膜特征，以解释着床调控及随后的妊娠丢失。在临床和研究背景下，根据不明原因复发性流产女性患者病理状态的可能性高低进行分层，将有助于挑选出最适合进一步检查及未来可能治疗的女性患者。
