Jiang Yishi, Zhang Yan, Li Yuyan, Che Yan
NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China.
Front Med (Lausanne). 2025 May 14;12:1554875. doi: 10.3389/fmed.2025.1554875. eCollection 2025.
Recurrent spontaneous abortion (RSA) represents a significant challenge in obstetrics and reproductive medicine. Causative factors in 40%-50% of RSA couples remain unknown, a condition termed unexplained recurrent spontaneous abortion (URSA). This study employed bibliometric analysis to elucidate global research trends and identify key areas of interest in URSA.
We utilized the Web of Science Core Collection (WoSCC), including Science Citation Index Expanded (SCI-EXPANDED) and Social Sciences Citation Index (SSCI), as our data source. Our search encompassed all publications on URSA published between 1 January 2014 and 30 October 2024. Following rigorous removal of duplicates, we retained 586 relevant publications, including 532 original articles and 54 reviews. We conducted bibliometric analysis using CiteSpace, VOSviewer and Microsoft Excel.
Analysis of annual publications and their citations demonstrated significant growth over the last 10 years. China, the United States and Iran emerged as the most productive countries in the field. Author distribution indicated the absence of a cohesive core author group, suggesting a dispersed research community. The top five cited publications included one prospective observational study, one randomized controlled trial, two reviews, and one immunohistochemistry study, focusing on the etiology, interventions, and therapies of URSA. Keyword cluster analysis identified six categories, with the top three keywords being "expression," "polymorphisms," and "regulatory T-cells."
This bibliometric analysis reveals three key research domains over the last decade in URSA: immunological mechanism and therapies, genetic mechanism, and anticoagulation therapies. While these areas have advanced our understanding, limitations persist in etiological heterogeneity and therapeutic inconsistencies. Future studies should prioritize rigorous multicenter trials with phenotypic stratification, and multi-omics approaches for mechanistic insights. Enhanced global collaboration and interdisciplinary integration are essential to transition from empirical management to evidence-based precision medicine in URSA.
复发性自然流产（RSA）是妇产科和生殖医学领域面临的一项重大挑战。40%-50%的RSA夫妇的致病因素仍不明确，这种情况被称为不明原因复发性自然流产（URSA）。本研究采用文献计量分析方法，以阐明全球研究趋势，并确定URSA领域的关键研究热点。
我们使用了Web of Science核心合集（WoSCC），包括科学引文索引扩展版（SCI-EXPANDED）和社会科学引文索引（SSCI）作为数据源。我们检索了2014年1月1日至2024年10月30日期间发表的所有关于URSA的出版物。在严格去除重复项后，我们保留了586篇相关出版物，其中包括532篇原创文章和54篇综述。我们使用CiteSpace、VOSviewer和Microsoft Excel进行文献计量分析。
对年度出版物及其引用情况的分析表明，在过去10年中该领域有显著增长。中国、美国和伊朗是该领域发文量最多的国家。作者分布表明缺乏一个有凝聚力的核心作者群体，这表明研究群体较为分散。被引用次数最多的前五篇出版物包括一项前瞻性观察性研究、一项随机对照试验、两篇综述和一项免疫组织化学研究，重点关注URSA的病因、干预措施和治疗方法。关键词聚类分析确定了六个类别，排名前三的关键词是“表达”、“多态性”和“调节性T细胞”。
这项文献计量分析揭示了过去十年中URSA的三个关键研究领域：免疫机制与治疗、遗传机制和抗凝治疗。虽然这些领域增进了我们的理解，但在病因异质性和治疗不一致性方面仍然存在局限性。未来的研究应优先开展严格的多中心试验，并进行表型分层，同时采用多组学方法来深入了解发病机制。加强全球合作和跨学科整合对于URSA从经验性管理向循证精准医学转变至关重要。
