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[脂多糖A类似物的合成。基于β-1,4-葡糖胺二糖（壳二糖）制备具有血清学活性的糖脂]

[Synthesis of lipid A analogs. Preparation of serologically active glycolipids on the basis of beta-1,4-glucosaminobiose (chitobiose)].

作者信息

Gorbach V I, Luk'ianov P A, Krasikova I N, Solov'eva T F, Ovodov Iu S

出版信息

Bioorg Khim. 1987 Oct;13(10):1409-15.

PMID:2449221
Abstract

Synthesis of beta-1,4-glucosaminobiose (chitobiose) 4'-phosphates N,N'-diacylated with (R)-3-hydroxymyristic acid is described, the structure being corroborated by 13C-NMR spectra. It was shown that activity of the components in various reactions with antibodies to lipid A from Yersinia pseudotuberculosis is similar to the lipid A activity.

摘要

描述了用（R）-3-羟基肉豆蔻酸对β-1,4-葡萄糖氨基二糖（壳二糖）4'-磷酸进行N，N'-二酰化的合成，其结构由13C-NMR光谱证实。结果表明，这些组分在与来自假结核耶尔森菌的脂多糖抗体的各种反应中的活性与脂多糖活性相似。

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