Gorbach V I, Solov'eva T F, Ovodov Iu S
Bioorg Khim. 1988 Apr;14(4):437-52.
Data on the synthesis of analogues of lipid A, a biologically active fragment of gram-negative bacteria's lipopolysaccharides, are summarized. Main types of the compounds obtained are systematized, and problems of the synthesis of various parts of the molecule considered. The results of studying biological activity of lipid A analogues are discussed, which led to some conclusions on the structure-function relation. Perspectives of further studies are briefly outlived.
本文总结了关于脂质A类似物合成的数据，脂质A是革兰氏阴性菌脂多糖的生物活性片段。对所获得化合物的主要类型进行了系统化整理，并考虑了分子各部分合成的问题。讨论了脂质A类似物生物活性的研究结果，得出了一些关于结构-功能关系的结论。简要概述了进一步研究的前景。
