组织胺毒素衍生物对牛蛙交感神经节中离子通道及乙酰胆碱受体-通道复合物的影响。

Effects of histrionicotoxin derivatives on ion channels and acetylcholine receptor-channel complexes in bullfrog sympathetic ganglia.

Ogura T, Warashina A

Department of Physiology, Niigata University School of Medicine, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;88(2):249-54. doi: 10.1016/0742-8413(87)90117-4.

Abstract

Four synthetic histrionicotoxin derivatives (H8-, H12-, C4H10- and C5H10-HTX) were applied to bullfrog (Rana catesbeiana) sympathetic ganglia and their effects were compared electrophysiologically. 2. The derivatives (60-100 microM) blocked both acetylcholine receptor-channel complex (ACh RC complex) and Na+ channel to cause a transmission failure. They also blocked K+ and Ca2+ channels. 3. Although all 4 derivatives exhibited similar effects, their potencies on respective ionic channels differed from one another. 4. Two types of (presumably subsynaptic and extrasynaptic) ACh RC complexes in ganglion cells were distinguished based on their differential sensitivities to HTX derivatives.

摘要

将四种合成的组织胺毒素衍生物（H8-、H12-、C4H10-和C5H10-HTX）应用于牛蛙（牛蛙）交感神经节，并通过电生理学方法比较它们的作用。2. 这些衍生物（60-100 microM）阻断乙酰胆碱受体通道复合物（ACh RC复合物）和Na+通道，导致传递失败。它们还阻断K+和Ca2+通道。3. 尽管所有4种衍生物都表现出相似的作用，但其对各自离子通道的效力彼此不同。4. 根据神经节细胞中两种（可能是突触下和突触外）ACh RC复合物对HTX衍生物的不同敏感性进行区分。