组织胺毒素对乙酰胆碱受体的抑制作用。
Inhibition of the acetylcholine receptor by histrionicotoxin.
作者信息
Anwyl R, Narahashi T
出版信息
Br J Pharmacol. 1980 Apr;68(4):611-5. doi: 10.1111/j.1476-5381.1980.tb10851.x.
Abstract
1 The action of C5-decahydrohistrionicotoxin (C5-HTX) has been investigated on the extrajunctional acetylcholine (ACh) receptors of denervated rat muscle. 2 C5-HTX causes both a rapid and slow reduction in amplitude of iontophoretic ACh potentials evoked at all frequencies from the extrajunctional receptors. 3 C5-HTX also causes a time-dependent inhibition of the iontophoretic potentials evoked at frequencies greater than 0.02 Hz. This inhibition was observed either alone or superimposed upon desensitization, and may be caused by a similar mechanism to desensitization.
摘要
- 研究了C5-十氢组氨毒素（C5-HTX）对去神经大鼠肌肉接头外乙酰胆碱（ACh）受体的作用。2. C5-HTX可使从接头外受体以所有频率诱发的离子电泳ACh电位幅度迅速和缓慢降低。3. C5-HTX还可对频率大于0.02Hz诱发的离子电泳电位产生时间依赖性抑制。这种抑制可单独观察到，也可叠加在脱敏之上，可能由与脱敏类似的机制引起。
相似文献
1
Inhibition of the acetylcholine receptor by histrionicotoxin.组织胺毒素对乙酰胆碱受体的抑制作用。
Br J Pharmacol. 1980 Apr;68(4):611-5. doi: 10.1111/j.1476-5381.1980.tb10851.x.
2
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Appearance of new acetylcholine receptors on the baby chick biventer cervicis and denervated rat diaphragm muscles after blockade with alpha-bungarotoxin.用α-银环蛇毒素阻断后，雏鸡颈二腹肌和去神经大鼠膈肌上新乙酰胆碱受体的出现。
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本文引用的文献
1
Junctional and extra-junctional acetylcholine receptors in skeletal muscle fibres.骨骼肌纤维中的接头处和接头外乙酰胆碱受体。
J Physiol. 1960 Apr;151(1):24-30.
2
Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current.组胺毒素对胆碱能受体离子电导调节剂的作用：终板电流的定量分析
J Pharmacol Exp Ther. 1974 May;189(2):513-24.
3
Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions.小鼠神经肌肉接头处的乙酰胆碱受体和离子电导调节位点：来自特定毒素反应的证据。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):949-53. doi: 10.1073/pnas.70.3.949.
4
5
6
Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.全氢组氨力农毒素：一种乙酰胆碱受体离子电导调节剂的潜在配体。
Proc Natl Acad Sci U S A. 1977 May;74(5):2172-6. doi: 10.1073/pnas.74.5.2172.
7
Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin.电鳐（Torpedo marmorata）细胞膜中的不同蛋白质成分携带乙酰胆碱受体位点以及局部麻醉药和组氨毒的结合位点。
Proc Natl Acad Sci U S A. 1978 Jan;75(1):510-4. doi: 10.1073/pnas.75.1.510.
8
Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor.组织胺毒素增强激动剂诱导的乙酰胆碱受体脱敏。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5754-8. doi: 10.1073/pnas.74.12.5754.
9
Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents.全氢组胺离子载体毒素对神经诱发和离子电泳诱发终板电流的不同影响。
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1596-9. doi: 10.1073/pnas.75.3.1596.
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