Haghpanah Tahereh, Afarinesh Mohammadreza, Divsalar Kouros
Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Addict Health. 2010 Winter-Spring;2(1-2):9-16.
Long-term use of opioids has acute effects on homeostasis of the body. Discovering the impacts of opioids on hematological parameters of narcotics withdrawal and dependents blood may be helpful in recognizing the homeostasis condition of their body for the useful treatment.
In this study a cross-sectional method was applied. The abusers of opium and heroin for more than two consecutive years were considered as opium and heroin dependent groups, respectively. The dependent people, who passed the 1-month withdrawal period, entered the study as opium and heroin withdrawal groups. In this study, hematological factors of heroin and opium dependent and withdrawal groups were investigated.
The RBC count remained unchanged in all groups. The WBC count had a significant increase in opium dependent group but in heroin dependent group and withdrawal group there was no significant difference. HGB level had a significant increase only in opium and heroin withdrawal groups. The percentage of HCT had a significant increase in all groups. The MCV increased in heroin and opium dependent groups. MCH level increased significantly in heroin and opium withdrawal groups. MCHC level had a significant increase in all groups. Neutrophil and lymphocyte counts in heroin and opium addicted groups significantly decreased. Platelet, neutrophil and monocyte counts significantly increased in opium dependent group. Monocyte countshowed a significant reduction in heroin withdrawal group. Eosinophil count showed no difference in any of the groups.
The current study indicated that not only the chronic and long-term use of opium and heroin, also withdrawal of addicted people could change hematological parameters related to human serum.
长期使用阿片类药物会对身体的内稳态产生急性影响。了解阿片类药物对戒毒者和依赖者血液血液学参数的影响，可能有助于识别他们身体的内稳态状况，从而进行有效的治疗。
本研究采用横断面研究方法。连续两年以上滥用鸦片和海洛因的人群分别被视为鸦片依赖组和海洛因依赖组。经过1个月戒毒期的依赖者作为鸦片戒断组和海洛因戒断组进入研究。在本研究中，对海洛因和鸦片依赖组及戒断组的血液学因素进行了调查。
所有组的红细胞计数均保持不变。白细胞计数在鸦片依赖组显著增加，但在海洛因依赖组和戒断组中无显著差异。血红蛋白水平仅在鸦片和海洛因戒断组显著增加。血细胞比容百分比在所有组中均显著增加。平均红细胞体积在海洛因和鸦片依赖组中增加。平均红细胞血红蛋白含量在海洛因和鸦片戒断组中显著增加。平均红细胞血红蛋白浓度在所有组中均显著增加。海洛因和鸦片成瘾组的中性粒细胞和淋巴细胞计数显著减少。血小板、中性粒细胞和单核细胞计数在鸦片依赖组显著增加。单核细胞计数在海洛因戒断组显著降低。嗜酸性粒细胞计数在任何组中均无差异。
本研究表明，不仅鸦片和海洛因的长期慢性使用，而且成瘾者的戒断都会改变与人体血清相关的血液学参数。
