Quraishi Rizwana, Kathiresan Preethy, Verma Kamini, Rao Ravindra, Jain Raka
National Drug Dependence Treatment Centre, AIIMS, New Delhi, India.
Department of Psychiatry, AIIMS, Jodhpur, Rajasthan, India.
Indian J Psychiatry. 2022 May-Jun;64(3):252-256. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_751_21. Epub 2022 Jun 8.
Chronic opioid use affects biological functioning implicating the hematopoietic and immune system. It may alter various hematological parameters and inflammatory markers. This study aimed to assess the association of opioid dependence with the hematological parameters and inflammatory markers in the Indian population.
A retrospective chart review was done among opioid dependent (ODS) males and healthy controls (HC) who visited the center's laboratory between Jan 2017 and Dec 2018 for hematological investigations. Clinical records reviewed for opioid use details like type, duration, and route of administration. The hematological profile presented as Mean or median. Mann-Whitney U test was used to compare the hematological parameters between the cases and controls.
The study included 191 ODS patients and 123 controls. Among ODS patients, a significant decrease in the levels of hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin and an increase in RBC count and lymphocytes was observed when compared to controls. The inflammatory markers, Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio, were significantly lower among ODS. Longer duration of opioid use leads to increased NLR among ODS patients. Opioid use by injection did not alter any of the hematological parameters compared to non-injection drug use.
Chronic opioid use has a significant effect on the hematopoietic cells. Opioid use for longer durations increases the inflammatory markers suggesting underlying infections.
长期使用阿片类药物会影响涉及造血和免疫系统的生物功能。它可能会改变各种血液学参数和炎症标志物。本研究旨在评估印度人群中阿片类药物依赖与血液学参数和炎症标志物之间的关联。
对2017年1月至2018年12月期间到该中心实验室进行血液学检查的阿片类药物依赖男性（ODS）和健康对照者（HC）进行回顾性病历审查。审查临床记录以获取阿片类药物使用细节，如类型、持续时间和给药途径。血液学指标以均值或中位数表示。采用曼-惠特尼U检验比较病例组和对照组之间的血液学参数。
该研究纳入了191名ODS患者和123名对照者。与对照组相比，ODS患者中观察到血红蛋白、平均红细胞体积和平均红细胞血红蛋白水平显著降低，红细胞计数和淋巴细胞增加。炎症标志物中性粒细胞-淋巴细胞比值（NLR）和血小板-淋巴细胞比值在ODS患者中显著较低。阿片类药物使用时间较长会导致ODS患者的NLR升高。与非注射吸毒相比，注射使用阿片类药物并未改变任何血液学参数。
长期使用阿片类药物对造血细胞有显著影响。长期使用阿片类药物会增加炎症标志物，提示存在潜在感染。
