Baek Ji Hyun, Kang Eun-Suk, Fava Maurizio, Mischoulon David, Nierenberg Andrew A, Yu Bum-Hee, Lee Dongsoo, Jeon Hong Jin
Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:113-8. doi: 10.1016/j.pnpbp.2014.01.018. Epub 2014 Feb 2.
Major depressive disorder (MDD) is associated with suicide. Although several studies have reported its association with low serum lipid, few studies have investigated relationships between current suicidality and lipid profiles, comparing with other blood measures in MDD patients.
The study population consisted of 555 subjects with MDD who were ≥ 18 years old, evaluated by the Mini International Neuropsychiatric Interview (MINI) with the suicidality module. At the evaluation visit, we measured serum lipid profiles including total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL), and blood measures such as fasting glucose, total protein, albumin, blood urea nitrogen, creatinine, thyroid hormones, red and white blood cells, platelet count, hemoglobin, and hematocrit.
Recent attempters who had attempted suicide within the past month showed significantly lower TG and higher HDL levels than lifetime and never attempters, using Tukey's post-hoc analysis. Recent attempters exhibited lower TG and higher HDL than those with recent suicide ideation and wish to self-harm and those without previous attempt. Linear regression analysis revealed that TG was negatively associated with current suicidality scores (β = -0.187, p = 0.039), whereas VLDL was positively associated with the recent suicide status (β = 0.198, p = 0.032) after controlling for age and sex. There were no significant differences between the groups in terms of other serum lipid profiles and blood measures.
Low serum TG, high HDL and VLDL levels are associated with recent suicide attempt or recent suicide status in patients with MDD.
重度抑郁症（MDD）与自杀有关。尽管有几项研究报告了其与低血清脂质的关联，但很少有研究调查当前自杀倾向与脂质谱之间的关系，并与MDD患者的其他血液指标进行比较。
研究人群包括555名年龄≥18岁的MDD患者，通过迷你国际神经精神病学访谈（MINI）的自杀倾向模块进行评估。在评估访视时，我们测量了血清脂质谱，包括总胆固醇、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和极低密度脂蛋白（VLDL），以及血液指标，如空腹血糖、总蛋白、白蛋白、血尿素氮、肌酐、甲状腺激素、红细胞和白细胞、血小板计数、血红蛋白和血细胞比容。
使用Tukey事后分析，过去一个月内有自杀未遂的近期未遂者的TG水平显著低于终身未未遂者和从未未遂者，HDL水平则更高。近期未遂者的TG水平低于有近期自杀意念和自伤意愿者以及无既往未遂史者，HDL水平则更高。线性回归分析显示，在控制年龄和性别后，TG与当前自杀倾向评分呈负相关（β = -0.187，p = 0.039），而VLDL与近期自杀状态呈正相关（β = 0.198，p = 0.032）。在其他血清脂质谱和血液指标方面，各组之间无显著差异。
低血清TG、高HDL和VLDL水平与MDD患者近期自杀未遂或近期自杀状态有关。
