Tatayeva Roza, Nurkatov Yerbol, Akbayeva Lyailya, Ilderbayev Oralbek, Makhanova Akmaral, Suleimenova Ainash
Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana , Kazakhstan.
Department of Health and Wellness Center, Nazarbayev University, Astana, Kazakhstan.
Med J Islam Repub Iran. 2025 Jan 27;39:15. doi: 10.47176/mjiri.39.15. eCollection 2025.
The article addresses one of the pivotal issues in the formation of suicidal behavior, namely the function of central and peripheral neurotransmitter systems and the mechanisms of neuroendocrine regulation. This article presents the relationship between alterations in lipid metabolism and suicidal behavior, as well as candidate genes of the serotonergic system involved in suicidal behavior.
The present study is a review of a number of published completed papers by systematically searching original articles in English in the following electronic databases: PubMed, SCOPUS, Mendeley, Google Scholar, and ScienceDirect between 2013 and 2023.
A total of 126 sources were used in the scientific literature review, covering findings from a range of disciplines, including biology, neurochemistry, anatomy, neurohormones, and serotonergic system candidate genes relevant to suicidal behavior.
The identification of neurobiological indicators of suicidality is of significant importance for the understanding of the pathophysiology of suicidality and for the search for peripheral markers that could be utilized to clarify risk, prediction, and, ideally, suicide prevention. The findings of this review underscore the intricate biological underpinnings of suicidal behavior, underscoring that suicidality is not merely a psychological or social phenomenon but rather a complex and deeply rooted system of neurobiological processes. The review suggests that biological markers should be integrated with existing psychological assessments to create a multidimensional profile of suicide risk.
本文探讨自杀行为形成过程中的一个关键问题，即中枢和外周神经递质系统的功能以及神经内分泌调节机制。本文阐述了脂质代谢改变与自杀行为之间的关系，以及参与自杀行为的血清素能系统的候选基因。
本研究通过在2013年至2023年期间系统检索以下电子数据库中的英文原创文章，对多篇已发表的完整论文进行综述：PubMed、SCOPUS、Mendeley、谷歌学术和ScienceDirect。
科学文献综述共使用了126篇文献，涵盖了一系列学科的研究结果，包括生物学、神经化学、解剖学、神经激素以及与自杀行为相关的血清素能系统候选基因。
自杀神经生物学指标的识别对于理解自杀行为的病理生理学以及寻找可用于阐明风险、预测并理想地预防自杀的外周标志物具有重要意义。本综述的结果强调了自杀行为复杂的生物学基础，强调自杀不仅仅是一种心理或社会现象，而是一个复杂且根深蒂固的神经生物学过程系统。该综述表明，生物标志物应与现有的心理评估相结合，以创建自杀风险的多维概况。
