固醇调节元件结合蛋白-2基因单核苷酸多态性与中国汉族人群膝骨关节炎风险的关联

Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population.

作者信息

Qiu Xiao-Ming, Jin Cheng-Tao, Wang Wei

机构信息

Department of Orthopaedics, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

J Int Med Res. 2014 Apr;42(2):320-8. doi: 10.1177/0300060513507392. Epub 2014 Feb 4.

DOI:10.1177/0300060513507392

PMID:24496149

Abstract

OBJECTIVE

To investigate associations between single nucleotide polymorphisms (SNPs) rs2228314 and rs2267443 in the sterol regulatory element binding protein-2 gene (SREBP-2) and knee osteoarthritis (OA) susceptibility in a Chinese Han population.

METHODS

SREBP-2 rs2228314 and rs2267443 polymorphisms were genotyped in patients with knee OA and age- and sex-matched OA-free controls from a Chinese Han population.

RESULTS

A total of 402 patients with knee OA and 410 controls were enrolled in the study. GC and CC genotypes of rs2228314, and variant C, were associated with a significantly increased risk of knee OA. On stratification analysis, the association between the risk of OA and rs2228314 GC heterozygotes compared with GG homozygotes was stronger in females and those aged >65 years. In contrast, the GA and AA genotypes of rs2267443 were not significantly associated with the risk of knee OA, even after further stratification analysis according to age or sex.

CONCLUSIONS

SREBP-2 rs2228314 G to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.

摘要

目的

研究固醇调节元件结合蛋白2基因（SREBP - 2）中的单核苷酸多态性（SNP）rs2228314和rs2267443与中国汉族人群膝骨关节炎（OA）易感性之间的关联。

方法

对来自中国汉族人群的膝骨关节炎患者以及年龄和性别匹配的无骨关节炎对照者进行SREBP - 2 rs2228314和rs2267443多态性基因分型。

结果

本研究共纳入402例膝骨关节炎患者和410例对照者。rs2228314的GC和CC基因型以及变异型C与膝骨关节炎风险显著增加相关。分层分析显示，与GG纯合子相比，OA风险与rs2228314 GC杂合子之间的关联在女性和年龄>65岁的人群中更强。相比之下，即使根据年龄或性别进行进一步分层分析，rs2267443的GA和AA基因型与膝骨关节炎风险也无显著关联。