中国汉族人群中固醇调节元件结合蛋白-2和肝脏X受体α基因单核苷酸多态性与多囊卵巢综合征风险的关联
Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 and liver X receptor α gene and risk of polycystic ovary syndrome in a Chinese Han population.
作者信息
Zhao Jianhong, Hu Zhiying, Cai Long, Liu Ling, Jiang Xijing, Wu Linzhen, Gong Junling
机构信息
Department of gynaecology and obstetrics, Hangzhou Red Cross Hospital, Hangzhou, 310003, Zhejiang Province, China.
出版信息
Cell Biochem Biophys. 2014 Nov;70(2):1421-6. doi: 10.1007/s12013-014-0075-5.
To investigate associations of single nucleotide polymorphisms (SNPs) rs2228314 of sterol regulatory element-binding protein-2 (SREBP-2) or rs11039155 of liver X receptor α (LXRα) with susceptibility to polycystic ovary syndrome (PCOS) in a Chinese Han population. SREBP-2 rs2228314 and LXRα rs11039155 polymorphisms were genotyped in patients with PCOS and age- and sex-matched PCOS-free controls from a Chinese Han population. A total of 605 patients with PCOS and 615 controls were recruited in this study. We found that GC and CC genotypes of rs2228314, and variant C, were associated with a significantly increased risk of PCOS. In addition, GA and AA genotypes of rs11039155, as well as variant A, were also associated with a significantly increased risk of PCOS. Our results showed that SREBP-2 rs2228314 G to C change and variant C genotype as well as LXRα rs11039155 G to A change and variant A may contribute to PCOS in Chinese Han population.
为研究在中国汉族人群中，固醇调节元件结合蛋白-2（SREBP-2）的单核苷酸多态性（SNP）rs2228314或肝脏X受体α（LXRα）的rs11039155与多囊卵巢综合征（PCOS）易感性之间的关联。对来自中国汉族人群的PCOS患者以及年龄和性别匹配的无PCOS对照者进行SREBP-2 rs2228314和LXRα rs11039155多态性基因分型。本研究共招募了605例PCOS患者和615例对照者。我们发现，rs2228314的GC和CC基因型以及变异型C与PCOS风险显著增加相关。此外，rs11039155的GA和AA基因型以及变异型A也与PCOS风险显著增加相关。我们的结果表明，在中国汉族人群中，SREBP-2 rs2228314的G到C改变及变异型C基因型，以及LXRα rs11039155的G到A改变及变异型A可能与PCOS有关。
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