Babakurban Seda Turkoglu, Erbek Selim S, Terzi Yunus Kasim, Arslan Fatih, Sahin Feride I
Department of Otolaryngology, Faculty of Medicine, Baskent University, 06490, Ankara, Turkey,
Eur Arch Otorhinolaryngol. 2014 Jul;271(7):2045-8. doi: 10.1007/s00405-014-2908-7. Epub 2014 Feb 5.
The objective of this study is to examine whether there is an association of fractalkine gene receptor polymorphisms with chronic tonsillitis. This is a cross-sectional study in the setting of a tertiary referral center. The study group included 79 patients with chronic tonsillitis and 76 controls without history of chronic tonsillitis. Genotypes were identified by restriction fragment length polymorphism analyses after polymerase chain reaction. c.745G>A (V249I) single nucleotide polymorphism and the frequencies of the G and A alleles did not differ in the patient and control groups (p = 0.363; p = 0.743, respectively). c.839C>T (T280M) single nucleotide polymorphism was found to be higher in controls than in the patients with chronic tonsillitis (p < 0.001). Consistent with this result, T allele frequency was higher in controls than in the patients with chronic tonsillitis (p < 0.001). In this study, we suggested that fractalkine gene receptor c.839C>T (T280M) single nucleotide polymorphism could be associated with a reduced risk of chronic tonsillitis.
本研究的目的是检验趋化因子基因受体多态性与慢性扁桃体炎之间是否存在关联。这是一项在三级转诊中心进行的横断面研究。研究组包括79例慢性扁桃体炎患者和76例无慢性扁桃体炎病史的对照者。通过聚合酶链反应后的限制性片段长度多态性分析来鉴定基因型。c.745G>A（V249I）单核苷酸多态性以及G和A等位基因的频率在患者组和对照组中没有差异（分别为p = 0.363；p = 0.743）。发现c.839C>T（T280M）单核苷酸多态性在对照组中高于慢性扁桃体炎患者（p < 0.001）。与该结果一致，T等位基因频率在对照组中高于慢性扁桃体炎患者（p < 0.001）。在本研究中，我们认为趋化因子基因受体c.839C>T（T280M）单核苷酸多态性可能与慢性扁桃体炎风险降低有关。
