如何制造肠子。
How to make an intestine.
机构信息
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
出版信息
Development. 2014 Feb;141(4):752-60. doi: 10.1242/dev.097386.
Abstract
With the high prevalence of gastrointestinal disorders, there is great interest in establishing in vitro models of human intestinal disease and in developing drug-screening platforms that more accurately represent the complex physiology of the intestine. We will review how recent advances in developmental and stem cell biology have made it possible to generate complex, three-dimensional, human intestinal tissues in vitro through directed differentiation of human pluripotent stem cells. These are currently being used to study human development, genetic forms of disease, intestinal pathogens, metabolic disease and cancer.
摘要
由于胃肠道疾病的高发率，人们对建立人类肠道疾病的体外模型以及开发更能准确反映肠道复杂生理学的药物筛选平台产生了浓厚的兴趣。我们将回顾一下，发育和干细胞生物学的最新进展如何使人们有可能通过定向分化人类多能干细胞在体外生成复杂的、三维的人类肠道组织。这些组织目前正被用于研究人类发育、遗传形式的疾病、肠道病原体、代谢疾病和癌症。
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