Novikov V I, Molotkov O V
Probl Endokrinol (Mosk). 1987 Nov-Dec;33(6):13-6.
The purpose of the paper is to define the state of glucocorticoid function in 37 male and female patients with types I and II diabetes mellitus of various degree of compensation before and after dexamethasone blockade of the hypothalamohypophyseoadrenal system (0.5 mg 4 times for 2 days). The level of cortisol in the plasma was determined by a radioimmunoassay using Sorin kits. Statistical data processing was performed using the d-3-28 computer. In patients with types I and II diabetes mellitus at the stage of compensation the level of plasma cortisol did not differ from that of persons without diabetes mellitus; in decompensation of types I and II diabetes mellitus its considerable increase was noted. After the dexamethasone test the more pronounced was a degree of decompensation of diabetes mellitus, the higher was the level of cortisol, i.e. there was resistance to dexamethasone inhibiting action, especially in type I which could be accounted for by deeper metabolic derangements in this type of diabetes mellitus and an increase in the threshold of sensitivity of the hypothalamic centers to dexamethasone. Therefore the minor dexamethasone test could be used for determination of a degree of metabolic compensation of patients with diabetes mellitus.
本文旨在确定37例不同代偿程度的I型和II型糖尿病男女患者在接受地塞米松阻断下丘脑 - 垂体 - 肾上腺系统（0.5毫克，每日4次，共2天）前后的糖皮质激素功能状态。采用索林试剂盒通过放射免疫分析法测定血浆皮质醇水平。使用d - 3 - 28计算机进行统计数据处理。在I型和II型糖尿病代偿期患者中，血浆皮质醇水平与非糖尿病患者无异；在I型和II型糖尿病失代偿期，血浆皮质醇水平显著升高。地塞米松试验后，糖尿病失代偿程度越明显，皮质醇水平越高，即对地塞米松的抑制作用存在抵抗，尤其是在I型糖尿病中，这可能是由于该型糖尿病存在更严重的代谢紊乱以及下丘脑中心对地塞米松的敏感性阈值升高所致。因此，小剂量地塞米松试验可用于测定糖尿病患者的代谢代偿程度。
