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[健康人地塞米松致皮质醇分泌降低]

[Depression of cortisol secretion with dexamethasone in healthy persons].

作者信息

Kolebinov N Kh, Ankov V K, Belovezhdov N I

出版信息

Vutr Boles. 1975;14(1):89-93.

PMID:1189401
Abstract
  1. Cortisol secretion inhibition in 70 healthy individuals was followed-up, after the peroral application of dexametason 2,5 mg/24. Plasma cortisol, with initial values of 18,8 +/- 0,64 mkg/100 ml was inhibited to 5,7 +/- 0,21 mkg/100 ml. The decrease is with 69,7 per cent of the basic level. 2. The indices for normal values were drawn as well as a positive hormonal response to dexametason: initial level between 6,3 and 29,4 mkg/100 ml, cortisol decrease at least with 4,8 mkg/100 ml plasma and the plasma cortisol level after 2,5 mg dexametason--under 9,9 mkg/100 ml. 3. In case of hormonal response absence to dexametason those three indices were not observed. The hormonal response is disturbed if the decrease is under 4,8 mkg/100 ml or the inhibitory level does not reach the values under 9,9 mkg/100 ml plasma.
摘要
  1. 对70名健康个体口服2.5毫克/24小时地塞米松后，进行了皮质醇分泌抑制的随访。血浆皮质醇初始值为18.8±0.64微克/100毫升，被抑制至5.7±0.21微克/100毫升。下降幅度为基础水平的69.7%。2. 绘制了正常值指标以及对地塞米松的阳性激素反应：初始水平在6.3至29.4微克/100毫升之间，皮质醇下降至少4.8微克/100毫升血浆，2.5毫克地塞米松后血浆皮质醇水平低于9.9微克/100毫升。3. 在对地塞米松无激素反应的情况下，未观察到这三个指标。如果下降幅度低于4.8微克/100毫升或抑制水平未达到血浆低于9.9微克/100毫升的值，则激素反应受到干扰。

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